The evidence base in e-Mental Health (eMH), especially telepsychiatry, is substantial, as we proceed in the third active decade of eMH services and sixth decade overall. eMH improves access to quality care for variety of disorders (e.g., depression, anxiety, dementia), treatments (evaluation, medication, therapy), and settings (psychiatric, primary care). It is as good as in-person care – and in some ways better. Some areas are being more thoroughly assessed (e.g., child and adolescent, service delivery models) by traditional research methodology. More work is needed in many areas, though, in terms of elementary quantitative and qualitative indices for the average or regular clinical service or how to implement and improve a program. Specifically, a semistructured approach to services and a practical evaluation approach are needed related to new innovations (digital connectivity between patients and doctors or social media).